Maybe, maybe not.
To get the prime time spot on ABC/ESPN/BTN, the USC-MN game would have to jump these games:
Florida at Tennessee (likely CBS game)
Notre Dame at Michigan State (ABC/ESPN/BTN all will want this one)
UCLA at Texas (a clear ABC prime time candidate)
Clemson at Auburn (a clear ESPN prime time candidate)
Arkansas at Georgia (a clear ESPN prime time candidate)
Nebraska at Washington (ABC prime time candidate)
Iowa at Arizona (ABC prime time candidate)
Arizona State at Wisconsin (BTN prime time candidate)
Mississippi State at LSU (ESPN possibility)
BYU at Florida State
Alabama at Duke
That's a fairly impressive list of games. I'd say the TV execs probably rate the USC-MN game as a middle of the pack option out of that bunch. If I had to guess, I'd say the USC-MN game will be at 2:30pm. And, for the record, USC played in the 2:30pm time slot five times last year and five times the year before.